three-component procedure for the synthesis chiral spirooxindolopyrrolizidines via catalytic highly enantioselective 1,3-dipolar cycloaddition of azomethineylides and 3-(2-alkenoyl)-1,3-oxazolidin-2-ones
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abstract
the catalytic highly regio-, diastereo-, and enantioselective synthesis of a small library of spiropyrrolizidineoxindolesvia a four-component 1,3-dipolar cycloaddition reactionof azomethineylides, derived from isatin, with electron-deficient dipolarophilewas described. the process occurs at room temperature in aqueous ethanol as a green solvent and in the presence of a bidendatebis(imine)–cu(ii)triflate complex as catalyst.the reaction mechanism is discussedon the basis of the assignment of the absolute configuration of the cycloadducts.
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Journal title:
international journal of bio-inorganic hybrid nanomaterialsجلد ۲، شماره ۴، صفحات ۵۰۳-۵۱۰
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